Artificial Bezoar Metronidazole Capsules

Medicine is the most common thing in life. It is very helpful in treating diseases. However, you should also be careful not to choose medicine arbitrarily, especially when you don’t understand your own disease and the medicine. You should not take treatment, otherwise it will harm your health. Artificial bezoar metronidazole capsule is a common medicine. It is easy to use and is also conducive to the treatment of diseases.

Many people are not clear about what diseases artificial bezoar metronidazole capsules can treat. When choosing it, you need to understand it so that you can make a good choice. The following is a detailed introduction to it.

Artificial bezoar metronidazole capsules:

[Ingredients] This product is a compound preparation, its components are: each tablet contains 200 mg of metronidazole and 5 mg of artificial bezoar.

[Properties] The contents of this product are yellow or slightly yellow granules or powder.

[Indications] Used for acute pericoronitis of wisdom teeth, local alveolar abscess, pulpitis, apical periodontitis, etc.

【Specifications】Metronidazole 200mg, artificial bezoar 5mg

【Usage and Dosage】Oral. Take 2 capsules at a time, 3 times a day.

【Adverse Reactions】

1. The most serious adverse reaction of this product is that it can cause epileptic seizures and peripheral neuropathy at high doses, the latter of which is mainly manifested as numbness and paresthesia of the extremities. In some cases, long-term use of the drug may cause persistent peripheral neuropathy.

2. Other common adverse reactions include:

(1) Gastrointestinal reactions, such as nausea, loss of appetite, vomiting, diarrhea, abdominal discomfort, taste changes, dry mouth, metallic taste in the mouth, etc.

(2) Reversible neutropenia.

(3) Allergic reactions, such as rash, urticaria, itching, etc.

(4) Central nervous system symptoms, such as headache, dizziness, syncope, paresthesia, limb numbness, ataxia and mental confusion.

(5) Other symptoms include fever, vaginal candidiasis, cystitis, dysuria, dark urine, etc., which are all reversible and will recover on their own after stopping the medication.

【Taboo】

1. It is contraindicated for patients who are allergic to metronidazole or azole drugs.

2. It is contraindicated for patients with active central nervous system diseases and blood diseases.

3. Pregnant women are prohibited from using.

4. Do not use if you are drinking alcohol.

【Notes】

1. Carcinogenic and mutagenic effects: Animal experiments or in vitro tests have found that this product has carcinogenic and mutagenic effects, but this has not been confirmed in humans.

2. If adverse reactions of the central nervous system occur during use, the drug should be discontinued immediately.

3. This product may interfere with the test results of alanine aminotransferase, lactate dehydrogenase, triglyceride, hexokinase, etc., causing their measured values ​​to drop to zero.

4. Do not drink alcoholic beverages during medication, as it may cause accumulation of acetaldehyde in the body, interfere with the oxidation process of alcohol, and lead to a disulfiram-like reaction. Patients may experience abdominal cramps, nausea, vomiting, headaches, facial flushing, etc.

5. In patients with impaired liver function, the metabolism of this product slows down, and the drug and its metabolites tend to accumulate in the body. The dosage should be reduced and the blood drug concentration should be monitored.

6. This product can be continuously cleared from gastric juice. In some patients, placement of a gastric tube for suction and decompression may cause a decrease in blood drug concentration. During hemodialysis, this product and its metabolites are rapidly cleared, so there is no need to reduce the dosage of this product.

7. If patients with Candida infection use this product, their symptoms will be aggravated and they need to be given antifungal treatment at the same time.

8. For patients with anaerobic infection and renal failure, the dosing interval should be extended from 8 hours to 12 hours.

9. When treating vaginal trichomoniasis, the sexual partner must be treated at the same time.

10. Before repeating a course of treatment, a white blood cell count should be performed.

【Drug Interactions】

1. Metronidazole can inhibit the metabolism of warfarin and other oral anticoagulants, enhance their effects, and cause prolongation of prothrombin time.

2. When used in combination with drugs that induce liver microsomal enzymes such as phenytoin sodium and phenobarbital, the metabolism of this product can be enhanced, the blood concentration of the drug can be reduced, and the excretion of phenytoin sodium can be slowed down.

3. When used in combination with drugs that inhibit the activity of liver microsomal enzymes, such as cimetidine, the metabolism and excretion of this product in the liver can be slowed down, and the blood elimination half-life (t1/2β) of this product can be prolonged. The dosage should be adjusted according to the results of blood drug concentration determination.

4. This product can interfere with the metabolism of disulfiram. When the two are used together, patients may experience mental symptoms after drinking. Therefore, patients who have used disulfiram within 2 weeks should not use this product again.

5. This product may interfere with the determination results of serum aminotransferase and lactate dehydrogenase, and may reduce the levels of cholesterol and triglycerides.

【Overdose】

The most serious adverse reactions of metronidazole are epileptic seizures and peripheral neuropathy at high doses, the latter of which is mainly manifested by numbness and paresthesia of the extremities. In some cases, long-term use of the drug may cause persistent peripheral neuropathy.

【Pharmacology and Toxicology】

Pharmacological Action

Metronidazole has a strong antibacterial effect on most anaerobic bacteria. The antimicrobial spectrum includes Bacteroides fragilis and other Bacteroides species, Fusobacterium, Clostridium perfringens, Eubacterium, Veillonella, Peptococcus, and Peptostreptococcus, etc. Its bactericidal concentration is slightly higher than the inhibitory concentration. The bactericidal mechanism of metronidazole has not been fully elucidated. The nitroreductase of anaerobic bacteria plays an important role in the energy metabolism of sensitive strains. The nitro group of this product is reduced to a cytotoxin, thereby acting on the DNA metabolism process of bacteria and causing bacterial death. Resistant bacteria often lack nitroreductase and are therefore resistant to metronidazole. Artificial bezoar has antipyretic and anti-inflammatory effects.

Through the above introduction, we have a good understanding of artificial bezoar metronidazole capsules, so when choosing it, you can choose it with confidence. However, it should be noted that when using it, there are some methods and methods, and it cannot be used at will, otherwise it will be harmful to human health. You must choose the best according to the doctor's advice.