How to cure Aconitum poisoning?

Aconitum can be used to treat diseases, but improper use can cause poisoning. After Aconitum poisoning, the body will experience symptoms such as vomiting, diarrhea, dizziness, etc., which are very harmful to human health and need to be treated in time. Aconitum poisoning needs to go to the hospital for gastric lavage in time. Never take some emetic drugs at home by yourself, otherwise it will delay the disease and cause serious harm to your health.

Aconitum contains highly toxic disilic acid alkaloids: mesoaconitine, hypoaconitine, aconitine, etc. The poisoning mechanism is mainly on the nerves and heart. In the nerves, it is mainly to first excite and then paralyze the sensory nerves and central nervous system. The mechanism of disappearance of warmth, pain, touch and pressure sensation may be that Aconitum directly or indirectly acts on the unmyelinated and thinner nerve fibers, thereby preventing the occurrence and conduction of impulses.

The reason may be that aconitine competes with calcium ions for the binding of phospholipids on the membrane, causing changes in the sodium transport channel, preventing the influx of sodium ions necessary for generating action potentials, thereby blocking the conduction of nerve impulses and affecting the binding of pain-related central endogenous neurotransmitters such as serotonin, catecholamines, acetylcholine, endorphins and other carcinogens to corresponding receptors.

Therefore, accidental ingestion of Aconitum should be treated immediately, and vomiting, gastric lavage and laxatives should be induced immediately in the early stages. Gastric lavage solution can be potassium permanganate and tannic acid solution. The catharsis agent can be injected into the stomach through a gastric tube after gastric lavage with sodium sulfate or magnesium sulfate. You can also use 2% saline high-level colon irrigation, but if it is medicinal wine, gastric lavage is generally not very meaningful. Give plenty of fluids to promote excretion of toxins. For patients with slow heartbeat and arrhythmia, 1-2 mg of atropine can be injected subcutaneously or intramuscularly. The injection can be repeated every 4-6 hours. For severe cases, 0.5-1 mg of atropine can be added to glucose solution and slowly injected intravenously. For symptomatic treatment, antiarrhythmic drugs (such as lidocaine) can be used for patients whose arrhythmias cannot be corrected after treatment with atropine. If severe arrhythmias occur, such as ventricular tachycardia or ventricular fibrillation, electric shock therapy may be used, and those with low blood pressure may be given pressor drugs. Respiratory depression, heart failure, etc. can be treated with appropriate measures.

Pharmacological effects of Aconitum kusnezoffii

1. Aconitum has obvious anti-inflammatory and analgesic effects, and has a cardiotonic effect, but excessive dosage can cause arrhythmia and eventually lead to cardiac depression;

2. Aconitine can cause arrhythmia and hypertension, and can also enhance the toxic effect of citrus aurantium G on the myocardium, and has a significant local anesthetic effect;

3. Aconitum polysaccharide can significantly reduce normal blood sugar;

4. Aconitum injection has anti-cancer effects and can inhibit gastric cancer cells.