The efficacy and function of Panax notoginseng saponins

Panax notoginseng is also known as Tianqi. Li Shizhen, a famous pharmacist in the Ming Dynasty, called it "priceless". Panax notoginseng is a dazzling pearl among the treasures of Chinese herbal medicines. The classic Qing Dynasty book on pharmacy, "Supplement to Compendium of Materia Medica", states that "wild ginseng is the best for replenishing qi and blood, and Panax notoginseng is the best for replenishing qi and blood. They have the same taste and effect, so it is called ginseng Panax notoginseng, and it is the most precious of Chinese herbal medicines." The application of Panax notoginseng has a long history. In 1578, Li Shizhen wrote about Panax notoginseng in his immortal classic book Compendium of Materia Medica: "This medicine has just been produced recently. It is used as an important medicine for wounds in the southern army and is said to have miraculous effects"; "It is a medicine for the blood of Yangming and Jueyin, so it can cure all blood diseases."

In the late Ming Dynasty in the 16th century, Panax notoginseng had been introduced into coastal cities and central and western regions, and became well-known throughout China as a special medicine for traumatic injuries and promoting blood circulation and removing stasis. Notoginseng total saponins are the most important component of Panax notoginseng and also the most important component obtained from Panax notoginseng.

Pharmaceutical efficacy and effects of Panax notoginseng saponins

Current pharmaceutical research shows that notoginseng total saponins are an important component of Panax notoginseng. Panax notoginseng total saponins have the following pharmaceutical and efficacy effects:

1. Effect on hyperlipidemia

A clinical trial was conducted using Panax notoginseng total saponins to study their lipid-lowering and anti-thrombotic effects in patients with hyperlipidemia. Results After treatment, the patients had obvious anti-platelet aggregation and fibrinolytic effects. The clinical medicine professional effects and the improvement of blood sugar level and blood thixotropy were better than those in the control experiment. Studies have shown that Panax notoginseng total saponins have obvious preventive and therapeutic effects on hyperlipidemia.

2. Effect on hyperviscosity urine syndrome

The patients with hyperviscouria were divided into a Panax notoginseng saponins group and an enteric-coated aspirin group. After a 4-week treatment course, the data showed that Panax notoginseng saponins had significant effects in reducing platelet surface specificity, inhibiting platelet adhesion and aggregation, anti-thrombosis, and promoting blood circulation, and were superior to aspirin.

3. Effect on hypertension

Using Panax notoginseng total saponins to treat hypertension can significantly reduce elevated blood pressure and relieve heart rate after 20 days of treatment. Data show that Panax notoginseng total saponins can significantly reduce MDA in hypertensive patients, significantly increase SOD, improve red blood cell deformation ability, and reduce red blood cell aggregation.

4. Anti-myocardial ischemia effect

Observations on the effects of Panax notoginseng total saponins on experimental myocardial ischemia found that Panax notoginseng total saponins can significantly improve the specific manifestations of cerebral ischemia on the cutaneous electrocardiogram, reduce the scope of myocardial infarction, and can dramatically reverse the left atrium and left ventricle function problems in patients with fatigue-type angina pectoris, and even restore them to normal.

5. Antiarrhythmic

The clinical trial showed that total saponins of Panax notoginseng could significantly reduce experimental ventricular premature beats in rats, significantly reduce the duration of arrhythmias, and significantly reduce the incidence of arrhythmias during reperfusion after acute myocardial infarction in rats.

6. Anti-pulmonary atherosclerosis effect

The effects of Panax notoginseng total saponins on rabbit diet-induced pulmonary atherosclerosis were observed. The results showed that Panax notoginseng total saponins can play an anti-AS role based on its anti-infection and antioxidant effects, have a protective effect on vascular smooth muscle cells, protect germ cells from the influence of high lipid red blood cells, and have a certain preventive effect on the occurrence and development of pulmonary atherosclerosis.

7. Anti-thrombotic effect, promoting blood circulation

The research on the effect of Panax notoginseng saponins on ET-1 and platelet function in patients with coronary heart disease showed that Panax notoginseng saponins can significantly reduce platelet surface specificity, inhibit platelet aggregation and adhesion, resist thrombosis, and promote blood circulation.

8. Anti-cardiocerebral ischemic effect

Notoginseng total saponins are used to treat cerebral infarction and cardiovascular and cerebrovascular diseases with cerebral ischemia. Data show that notoginseng total saponins have very good clinical therapeutic effects on acute symptoms of cerebral infarction. Notoginseng total saponins can significantly improve brain edema during the reperfusion period of global cerebral ischemia or focal cerebral ischemia.

9. Promote the growth and development of hematopoietic cells

Notoginseng total saponins have a reproductive effect on hematopoietic progenitor cells. Scientific research has also found that Rg1 and Rb1 in Notoginseng total saponins are effective separate agents for promoting hematopoietic function, and can continuously promote the proliferation of human bone marrow granulocyte and erythroid hematopoietic progenitor cells, and have a better effect on granulocyte progenitor cells than on erythroid progenitor cells.

10. Anti-fibrosis process

Studies at the cellular level have found that Panax notoginseng saponins can alleviate the whole process of renal tubular damage-interstitial fibrosis and improve renal function. Experiments have found that Panax notoginseng saponins can delay the onset of bronchitis, slow down the progression, reduce the severity, and hardly cause pulmonary fibrosis.

Based on clinical trials, research on the effect of Panax notoginseng total saponins on experimental liver fibrosis. The data show that Panax notoginseng saponins have significant anti-liver fibrosis effects.

11. Protective effect on neuronal damage

Based on the detection of cytological, histological and lipid peroxidation damage indexes, the protective effect of Panax notoginseng total saponins model linear fitting germ cells was observed. The data showed that Panax notoginseng total saponins had a protective effect on neuronal damage caused by oxidative phosphorylation inhibition.