The efficacy and function of Millettia reticulata

There are many Cistanches in Xishuangbanna, my country. This is a plant that can bleed. This description makes Cistanches full of mystery. What are the effects and functions of Millettia reticulata? Is it really as magical as the legend says? Millettia reticulata has a good effect of nourishing blood and activating blood circulation. If female friends have irregular menstruation, taking a certain amount of Millettia reticulata can improve it. The effect of nourishing blood and regulating menstruation is very significant.

The efficacy and function of Millettia reticulata

Some friends who often experience numbness and cold hands and feet in life are mostly suffering from blood stasis. At this time, the effect and function of Millettia reticulata are very significant. It can help friends to relax muscles and promote blood circulation. Millettia reticulata also has a certain insecticidal effect.

Pharmacological effects of Millettia reticulata

1. Effect on the hematopoietic system: According to He Shuma et al., the decoction of the dense-flowered bean vine (100%) has a blood-tonifying effect on experimental rabbit anemia, which can increase blood cells and hemoglobin. It has a stronger effect than that of Millettia odorata. In 1989, Zhang Shufang et al. reported that Millettia reticulata decoction (2 g/kg) had no significant effect on the recovery of peripheral cells, hemoglobin and reticulocytes in rabbits with hemorrhagic anemia: the experiment used 7 litters of rabbits, 5 of which had 4 rabbits each, and the remaining 2 litters had 2 rabbits each, for a total of 24 rabbits. There are 13 females and 11 males, weighing 1.42-2.58kg. Four rabbits from the same litter were randomly divided into three groups: Danshen, Angelica, Millettia reticulata, and a control group, with 5 rabbits in each group. The normal values ​​were only observed for the other 4 mice. During the experiment, blood was collected from the ear vein at 8:30 am every day (after the first feeding) to measure hemoglobin, red blood cell count, and reticulocyte count. After the values ​​of the three indicators became constant, they were measured continuously for 3 days and used as the normal values ​​for the rabbit. Starting from the 4th day, blood was let out from the V-shaped incision at the tip of the rabbit's ear at 8:30 am every day. Once a day for 3 consecutive days, each bloodletting is equivalent to 1% of the body weight on that day, and the total bloodletting volume is equivalent to 50% of the total blood volume. After bloodletting, 5% glucose solution was gavaged to replenish lost body fluids, with the dosage being 1% of body weight. Starting from one day after the bloodletting, each group was gavaged with 20% decoction of Salvia miltiorrhiza, Angelica sinensis, and Millettia reticulata at a dose of 2 g per 1 kg body weight. The other group was given 10 ml of normal saline per 1 kg body weight as a control, once a day for 10 consecutive days. Blood was drawn from the ear vein at 8:30 am every day from 1 to 13 days and on days 16, 18, and 21 after the bloodletting to check the blood count. Taking the red blood cell count and hemoglobin value before bloodletting as 100%, the average number of days for each group of rabbits to recover to 95% after bloodletting are shown in Tables 1 and 2 respectively; taking the normal value of reticulocytes before bloodletting as 100%, the peak time of reticulocytes after bloodletting and its level 21 days later are shown in Table 3. The above results show that Millettia reticulata has no significant effect on the recovery of red blood cells, hemoglobin and reticulocytes in the ear vein of rabbits with hemorrhagic anemia.

2. Effects on coagulation and fibrinolysis: In the experiment on the effects on the coagulation and fibrinolysis process of canine blood in vitro, the femoral artery was exposed after anesthesia, and blood was collected (the test tube was placed in ice immediately after blood collection). 1 part of anticoagulant (sodium oxalate, sodium citrate) was added to 9 parts of whole blood, and the plasma was separated by centrifugation. The plasma was divided into 3 parts, and 0.03 ml of normal saline, salvia miltiorrhiza injection, and millettia spatholobi injection were added to each of them. Determine the recalcification time (reflecting the intrinsic coagulation process), prothrombin time, thrombin coagulation time, plasma fibrinogen quantification and globulin lysis test. It can be seen that Millettia reticulata (containing 3 mg of crude drug per 1 ml) has no obvious effect on the coagulation and fibrinolysis process of isolated dog blood.

3. Inhibitory effect on the heart and lowering blood pressure: 50% Millettia reticulata decoction has a slight inhibitory effect on the isolated and in vivo hearts of toads. Administration of 0.43-0.5g of the herb/kg decoction to anesthetized rabbits and 0.3g of the herb/kg decoction to dogs can cause a drop in blood pressure; however, it has a constrictive effect on isolated rabbit ears and toad blood vessels.

4. Anti-cancer effect: In vitro test dose of 500 micrograms (hot water extract)/ml, the inhibition rate of JTC-26 was 94.4%; phage method was used to screen anti-tumor drugs, and this product had anti-phage effect.

5. Regulation of lipid metabolism: Japanese quail were gavaged with 6g/kg of Millettia reticulata decoction for 14 days and 47 days, which could increase HDL2-C, reduce HDL3-C, and increase the ratio of HDL2-C/HDL3-C. This ratio is an important indicator for evaluating lipid metabolism and arteriosclerosis.

The diameter of Millettia spatholobi can generally reach between 2-7 cm, and it is difficult to break at the root. Millettia reticulata has a certain bitter smell, but as a medicinal material it does not affect friends' use and does not bring too much burden. We have introduced a lot of the effects and functions of Millettia reticulata above, and I hope you can make full use of them.