Benefits of Litsea cubeba root

The root of the catalpa ovata is a common plant, but it is not just a plant. It can also be used as a Chinese medicinal material, and its medicinal value is quite extensive. It can be used to treat many difficult-to-cure diseases, such as heart disease. If you often feel myocardial ischemia, you can take this Chinese medicinal material to improve your myocardial ischemia and play a protective role.

1. Antiplatelet aggregation effect In vitro experiments showed that citral at a concentration of 0.5 mg/ml can significantly inhibit collagen or ADP-induced rat platelet aggregation, and inhibit arachidonic acid-induced human platelet aggregation. Oral administration of 1g/kg citral to rats can also inhibit ADP-induced platelet aggregation. The mechanism may be due to preventing the generation and release of TXA2-like substances in platelets.

2. Anti-myocardial ischemia and myocardial infarction effect: Oral administration of 0.3 ml/kg of Litsea cubeba oil has a protective effect on acute myocardial ischemia in rabbits induced by injection of isoproterenol, reduces ST segment elevation in acute myocardial ischemia, and reduces the number of pathological Q waves. In the acute myocardial infarction model caused by ligation of the anterior descending coronary artery, Litsea cubeba oil can reduce the percentage of myocardial infarction shown by nitro blue tetrazolium staining. Litsea cubeba oil can increase coronary flow in isolated rabbit hearts. It has a dilating effect on the isolated coronary arteries of normal pigs and can antagonize the coronary contraction caused by adrenaline and norepinephrine. Intraperitoneal injection of 0.5ml/kg of Litsea cubeba oil and 10ml/kg of 10% pellet solution in mice can significantly prolong their survival time under normobaric hypoxia conditions. Litsea cubeba oil can also prolong the survival time of mice injected intraperitoneally with isoproterenol under normobaric hypoxia conditions, and has a relieving effect on potassium cyanide and sodium nitrite poisoning.

3. Antiasthmatic and anti-allergic effects: Litsea cubeba oil (bath concentration is 90 μl/ml) can relax the isolated tracheal smooth muscle of guinea pigs and relieve the spasm of tracheal smooth muscle caused by acetylcholine or histamine. This effect cannot be antagonized by propranolol. Gavage of 0.3 ml/kg of Litsea cubeba oil to guinea pigs and intraperitoneal injection of 0.1 ml/kg had a significant protective effect against bronchial spasm induced by spray of a mixture of 0.25% histamine and 2% acetylcholine (1:2). Citral is its main ingredient for relieving asthma. Passive skin allergy tests in rats, guinea pig anaphylactic shock and guinea pig isolated ileum allergy tests have proved that Litsea cubeba oil has obvious anti-allergic effects and also has obvious antagonistic effects on guinea pig intestinal segments caused by slow-reacting substances, indicating that the anti-asthmatic effect of Litsea cubeba oil, in addition to bronchial dilation, is also related to the formation and release of anti-allergic mediators.