What are the effects and functions of Mudanpi

Mudanpi is a traditional Chinese medicine, mainly produced in Anhui, Sichuan, Henan and other regions. It has the effects of clearing heat and cooling blood, promoting blood circulation and removing blood stasis, and its toxicity is also very low. It is mainly used clinically to treat diseases such as heat entering the blood, warm toxic spots, dysmenorrhea and traumatic injuries. However, patients with spleen and stomach deficiency and coldness cannot use this medicine. So what are the effects and functions of Mudanpi?

First, what are the effects and functions of Mudanpi? Clearing away heat; promoting blood circulation and dispersing blood stasis. It is used for febrile diseases with heat entering the blood; rash; vomiting and bleeding; hot eyes; fever in the yin organs due to late-stage bacterial infection; hot flashes due to yin deficiency and bone steaming; blood stasis and amenorrhea; dysmenorrhea; carbuncle, swelling and sore; pain from falls and injuries; and rheumatism and heat arthralgia.

Second, the effect on cardiovascular system: Moutan bark can increase coronary blood flow, reduce cardiac output and lower left ventricular work in anesthetized dogs. It has a significant protective effect on experimental myocardial ischemia, which lasts for a long time and reduces myocardial oxygen consumption. Effects on the central nervous system: Paeonol has an antipyretic effect on fever in mice caused by oral administration of typhoid and paratyphoid vaccines, and reduces the body temperature of normal mice. Oral administration of paeonol can inhibit the writhing reaction and tail tenderness reaction of mice caused by intraperitoneal injection of acetic acid, counteract the hyperactivity of mice caused by caffeine, significantly prolong the sleep time of mice induced by cyclohexylbarbital sodium, and at high doses can cause the righting reflex of mice to disappear. It can significantly counteract the convulsions caused by pentylenetetrazol, strychnine, nicotinic acid and electric shock. The sites of action are the midbrain reticular formation and thalamus.

Third, anti-inflammatory effect: intragastric administration of paeonol can inhibit the plantar edema of rats caused by dextran, acetic acid or carrageenan, and can inhibit the enhanced capillary permeability of the mouse abdominal cavity or guinea pig skin caused by acetic acid or 5-hydroxytryptamine, and inhibit the occurrence of stress ulcers in mice.

What are the effects and functions of Mudan Cortex? Antibacterial effect: In vitro experiments show that the decoction of Mudan Cortex has a strong antibacterial effect on Bacillus subtilis, Escherichia coli, Salmonella typhi, Salmonella paratyphi, Proteus, Pseudomonas aeruginosa, Staphylococcus, hemolytic Streptococcus, Pneumococcus, Vibrio cholerae, etc. The decoction of peony leaves has a significant antibacterial effect on Shigella dysenteriae, Pseudomonas aeruginosa and Staphylococcus aureus, and its active ingredient is gallic acid. Anticoagulant effect: In vitro tests on human platelets showed that both the water extract of Paeonia lactiflora and Paeoniflorin can inhibit the production of thromboxane A2 by platelet arachidonic acid, thereby inhibiting platelet aggregation. This is due to the inhibition of the cyclooxygenase reaction from arachidonic acid to prostate H2. The methanol extract of Paeonia lactiflora has the effect of inhibiting experimental thrombosis caused by endotoxin.