Side effects of white peel

Many people don’t know what Dictamni Cortex is. In fact, it is a common Chinese medicinal material with a wide range of medical uses. However, it should be noted that not everyone can use Dictamni Cortex. Some patients with spleen and stomach deficiency cannot eat it. If they take it, their spleen and stomach deficiency will become more serious, and the effect of treating the disease cannot be achieved.

Other effects: The mixture of dioscorea alkaloids, cypermethrin and capsularine can reduce the effect of adrenaline on the seminal vesicles of guinea pigs. Cypermethrin can paralyze muscles and cause a progressive decrease in blood pressure in mammals due to myocardial involvement. Artemisia selengensis can increase the tension of skeletal muscle and enhance the excitability of spinal reflexes. Fenugreek alkaloids have weak pharmacological activity. They can reduce the duration of nerves in neuromuscular specimens, while first reduce and then increase the duration of muscles. In addition, fenugreek alkaloids have certain anti-cancer effects. 12.5 mg/kg can extend the life of P388 leukemia mice by 31%.

Pharmacology (toxicology): The LD50 of dioscorea alkaloids, zanthoxylum alkaloids, and cypermethrin for mice is similar, which is 150-250 mg/kg for intraperitoneal injection; the LD50 of fenugreek alkaloids for subcutaneous injection in rats is 5.0 g/kg.

Taboo

It is contraindicated for patients with spleen and stomach deficiency and cold syndrome.

1. "Compendium of Materia Medica" says: "It is incompatible with silkworms, platycodon, tuckahoe, and radix polygoni multiflori."

2. "Ben Cao Jing Shu": "People with coldness in the lower body should not use it even if they have dampness symptoms."

clinical

Animal experimental models were used to observe the anti-allergic effect of Dictamni cortex extract, and its anti-allergic mechanism and the application of Dictamni cortex in eczema were preliminarily explored. method:

1. The rat passive skin sensitization method was used to establish a type Ⅰ allergic reaction animal model, and the diameter of the blue reaction spot on the back of the rat was observed;

2. Use histamine to induce local itching in guinea pigs, and observe the total amount of histamine phosphate given when the guinea pigs turn their heads to lick the scratches; 3. Dinitrochlorobenzene was used to induce type IV allergic reaction in mice, and the swelling of the ear pinnae was observed.

result:

1. High, medium and low doses of Dictamni cortex extract can significantly inhibit the diameter of blue reaction spots on the back skin of rats, P<0.01, indicating that Dictamni cortex extract has an inhibitory effect on type Ⅰ hypersensitivity.

2. The itch threshold of the high- and medium-dose groups of Dictamni extract was significantly higher than that of the control group, P<0.05, indicating that Dictamni extract has a significant local antipruritic effect.