The efficacy and function of Dabaijie potato

Dabaijieshu is a medicinal material and is quite common in life. We can eat Dabaijieshu appropriately. Since many people don’t know much about Dabaijieshu, let’s take a look at it below.

[Alias] Gold and silver bag, general manager, Radish Stephania tetrandra, and Aucklandia grandis.

[Source] Medicinal material source: The tuberous root of Aristolochia guangxiensis, a plant of the Aristolochiaceae family.

[Original form] A large woody vine of Aristolochia sinica. The tubers are oval or spindle-shaped, and often connected in pairs. The young branches are ridged and densely covered with dirty yellow or light brown long stiff hairs. The petiole is 6-15cm long, densely covered with long stiff hairs; the leaf blade is thick papery to leathery, ovate-cordate or rounded, 11-25cm long, 9-22cm wide, obtuse or mucronate at the apex, broadly cordate at the base, with entire margins, sparsely covered with long stiff hairs on the upper surface of young leaves, densely covered with dirty yellow or light brown long stiff hairs on both sides of growing leaves, with 5 basal veins and obvious bulges below the reticulate veins. The racemes are axillary, with 2-3 flowers; the pedicels often bend downward, densely covered with dirty yellow or light brown long stiff hairs; the bracts are awl-shaped, densely covered with long stiff hairs; the perianth tube is sharply bent in the middle, and the bend to the eaves is nearly as long and narrow as the lower part, light green on the outside, with brown longitudinal veins and longitudinal ridges, densely covered with light brown long stiff hairs, and glabrous on the inside; the eaves are disc-shaped, blue-purple on the upper side with dark red thorn-like protrusions, with reticulate veins, densely covered with brown long stiff hairs on the outside, with shallow 3-lobed edges, the lobes are broadly triangular, the apex is short-pointed, the throat is nearly round, yellow, and slightly protruding into a collar-like shape; the anthers are paired and attached to the syncytium near the base; the ovary is cylindrical, with 6 ridges; the edges of the syncytium lobes extend downward and roll up, with nipple-like protrusions. The capsule is dark yellow, oblong, 8-10cm long, with 6 ribs, and splits into 6 petals from the tip downward when ripe. Seeds oval. The flowering period is April-May, and the fruit ripening period is August-September.

【Habitat distribution】Ecological environment: Grown in valley forests.

【Properties】 Characteristic identification: The root tuber is large, spindle-shaped, and 30-60cm long. The surface is brown, sometimes with roots or root marks. It is firm and hard, and the cross section is white.

[Chemical composition] The root contains allantoin, aristolochic acid A, β-sitosterol, 6-methoxydenitroaristolochic acid methyl ester and 6-methoxyaristolochic acid A methyl ester. The tuberous roots also contain magnoflorine.

[Pharmacological action] 1. Analgesic effect: Total bioalkali extracted from Aristolochia guangxi can significantly inhibit the acetic acid-induced writhing reaction of mice after intraperitoneal injection, with an ED50 of 176.55 mg/kg, and the effect lasts for 2 hours. Intraperitoneal injection or intraventricular injection of total bioalkali can significantly increase the pain threshold of mice. There was no significant effect on the skin temperature of the mouse paws. The analgesic effect of total alkali is strongest 30 minutes after administration and lasts for more than 2 hours, and the analgesic intensity increases with increasing dose. When 1/125 (2.4 mg/kg) of the intraperitoneal injection dose of 300 mg/kg is injected into the ventricle, the analgesic intensity and duration of action are comparable to those of intraperitoneal administration, indicating that the analgesic effect of total alkali is not due to lowering the skin temperature of the soles of the feet, but involves the central nervous system. Naloxone cannot antagonize the analgesic effect of total alkali, indicating that it is not related to opioid receptors in the brain.

[Toxicity] Total alkali was injected intraperitoneally into mice at a dose of 1g/kg, and no mortality occurred within 24 hours. After a single intramuscular injection of 8 mg/kg of total alkali, the dog became quiet, less active, and ate less, but returned to normal within 10 to 64 hours. The LD50 of aristolochic acid (mainly aristolochic acid A) administered orally to mice is 47.87±8.25 mg/kg. After oral administration, the mice showed reduced activity, closed their eyes, erected their hair, and reduced their food intake. They began to die on the 4th day and this lasted for 12 days. Rabbits were given 6 mg/kg orally once a day. They began to eat less on the third day and refused to eat on the fifth day. Three rabbits in the group died. Pathological histological examination showed morphological changes of acute renal failure. Rabbits were given 1.5 mg/kg orally, once a day. On the 8th day, one of the three rabbits died. The non-protein nitrogen (NPN) of the other two rabbits increased significantly on the 8th day after administration and 6 days after drug withdrawal, and returned to normal 16 days after drug withdrawal. Pathological histological examination showed degeneration of renal tubular epithelium and casts in renal tubules. Three dogs were gavaged with 0.8 mg/kg daily for 35 consecutive days and showed symptoms of decreased appetite, anorexia, and weight loss. After the end of the administration, the serum alanine aminotransferase of one dog was slightly elevated, but no abnormalities were found in the other dogs.

【Nature and flavor】 Bitter; cold; slightly toxic

【Meridian】 Heart; stomach; large intestine

【Functions and indications】 Regulating qi and relieving pain; clearing away heat and detoxifying; stopping bleeding. It is mainly used for spasmodic stomachache, abdominal pain, acute gastroenteritis, gastric and duodenal ulcers, dysentery, traumatic injury, carbuncle, swelling and infection, traumatic bleeding, snake bites, and bone tuberculosis.

[Usage and Dosage] For oral use: decoction, 6-9g; grind into powder, 1.5-3g. For external use: take appropriate amount, grind the dry product into powder and sprinkle on the affected area; or mash the fresh product and apply it.

【Excerpt】 Chinese Materia Medica

Nowadays, people's life pressure is constantly increasing, which makes our bodies often in a state of fatigue. As a traditional Chinese medicine, Dabaijieshu has a certain regulating effect on the body. I hope it will be helpful to everyone.