What are the medicinal values ​​of red vine

Red vine is a traditional Chinese medicinal material with very high medicinal value. It not only has the effect of promoting blood circulation and removing blood stasis, but also can clear away heat and detoxify. It is precisely because of such effects that it is deeply loved by Chinese medicine practitioners. Many Chinese medicine practitioners will directly add red vine to the prescriptions they prescribe, but many people do not understand the medicinal value of red vine, so they cannot use red vine correctly.

1. Effects on the cardiovascular system

1.1 Effect on isolated toad heart According to the Yagi isolated heart apparatus, 20 ml of Ringer's solution was used to perfuse

Flow, 0.1g of red vine was added to the perfusion fluid (0.5%), and it was found that it had a mild inhibitory effect on the isolated heart, with weakened cardiac contractility, slower heart rate (P<0.05), and reduced cardiac output (P<0.01).

1.2 Effect on isolated rabbit aortic strips The isolated rabbit aortic strips were placed in the water tank of the isolated apparatus (37±0.5 degrees) for 1 hour, and 0.2 ml of the extract (1 g of crude drug/ml) was added to 20 ml of Klein's solution (1%). As a result, the blood vessels began to show obvious contraction, which could be blocked by phentolamine, suggesting that its contraction may be related to the a-receptor. Then a lasting relaxing effect gradually appears.

1.3 The experimental method for the effect on isolated porcine coronary artery was the same as above. 0.2 ml of the extract was added to 20 ml of Klein's solution, and norepinephrine and potassium chloride were used as positive and negative reaction controls. The effect after one hour was similar to that of the rabbit aorta strips. However, when the drug is added to the contraction state caused by potassium chloride, the contraction effect no longer occurs and the blood vessels relax immediately, suggesting that it is beneficial for the treatment of coronary artery spasm.

2. Effects on cyclic nucleotides in mouse plasma Healthy male guinea pigs, weighing 18-24g, were divided into 3 groups, 5 in each group. The first group was given 3g/kg (equivalent to 1/4LD50) of Red Caulis aqueous extract ip daily, the second group was given 200mg/kg of Danshensu ip daily, and the third group was given normal saline ip daily as a control for 7 consecutive days. One hour after the last day of administration, blood was collected from the eye sockets to measure the levels of cAMP and cGMP in plasma. Results The levels of cAMP in plasma in both the Caulis Sargentodoxae group and the Salvia miltiorrhiza group increased significantly, while the levels of cCMP did not decrease significantly. Another group of 5 mice was given 3 g/kg ip once, and blood was collected from the eye sockets every 15, 30, 90 and 120 minutes. Each group had a normal saline control. Observe the changes of cAMP and cGMP in plasma at different times. The results showed that within 50 minutes after administration, the levels of cAMP and cGMP increased, with the increase in cAMP being more obvious. The cAMP/cGMP value decreased, but after 60 minutes, the amount of cAMP and cCMP gradually decreased, and the cAMP/cGMP value increased. 100 mg/kg of water-soluble extract of Red Caulis Scutellariae can significantly increase the plasma cAMP of rabbits.

3. Effect on platelet aggregation: In vitro tests on the water-soluble extract of Sargentodoxae have a significant inhibitory effect on ADP-induced rabbit platelet aggregation and promote disaggregation, with an ID50 of 14.6 mg/ml. The water-soluble extract of Red Caulis has an inhibitory effect on ADP-induced platelet aggregation in rats at 40 and 100 mg/kg. The dichloromethane extract of this product, including dihydroguaiaretic acid, can inhibit the binding of PAF (platelet activating factor) to receptors.

4. Effect on the tolerance of mice to hypoxia under normal pressure. Healthy male mice weighing 17-22g were divided into 3 groups, with 10 mice in each group. They were given 2g (equivalent to the raw drug)/kg of red vine water extract, and the LD50 of mice by ip is 11.83±2.12g/kg). The control group was given the same volume of normal saline and observed regularly. Respiratory arrest was the indicator of death. The results showed that there were obvious effects at different time intervals.

The above article introduces in detail the medicinal value of red vine. In fact, this medicinal material has a better effect on the cardiovascular system than treating other diseases. Therefore, it is very suitable for the elderly to eat, and it can improve their cardiovascular diseases.