What are the effects of Angelica dahurica

I believe everyone has heard of Angelica dahurica, which appears in traditional Chinese medicine. Angelica dahurica is a common perennial herb. It is white in color and has a fragrant taste. It is an ancient traditional Chinese medicinal material in my country. It is also very helpful in the treatment of some diseases. So, what are the effects of Angelica dahurica? This is a question that many people want to know clearly.

Effects of Angelica dahurica

1. The traditional effects of Angelica dahurica include dispelling wind, drying dampness, reducing swelling and relieving pain. It is usually used to treat headaches, bone pain, toothache, abdominal pain, itchy skin and other problems. Angelica dahurica is a unique medicinal material in Wushan and a famous analgesic. Later, it began to be used slowly throughout the country.

2. Angelica dahurica can make the central nervous system feel excited and boost spirits. However, you need to pay attention to the dosage. A small amount can excite the central nervous system, such as the motor center, respiratory center, and spinal system. However, if the dose is large, it can easily cause convulsions, paralysis, etc., so you need to pay attention to the dosage.

3. Open the orifices and relieve pain. The great poet Su Shi once suffered from headaches and nasal congestion. Later, a monk brought him a packet of medicinal herbs and asked him to boil a soup and drink it. Unexpectedly, the medicine went straight into his nasal passages and made him feel a fresh air. It turned out that this medicine was Angelica dahurica, also known as "Fragrant Angelica dahurica" ​​and "Hangzhou Angelica dahurica".

4. Angelica dahurica can also lower blood pressure. It contains isoimperatorin and Indian quince, which can lower blood pressure. It also has antibacterial and anti-inflammatory effects.

5. Angelica dahurica also has the effects of inhibiting fat synthesis, relieving fever and pain, stopping bleeding, and relieving asthma.

6. Treat menstrual discomfort. Legend has it that during the Northern Song Dynasty, a wealthy businessman's daughter suffered from unbearable pain every time she had her menstruation, and her body became increasingly weak. The businessman was very anxious and prepared to take his daughter to the capital to seek treatment from a famous doctor. Later, he met an old man who sold her herbs. After finding out about her condition, he took out a portion of Angelica dahurica from his medicine basket and gave it to his daughter, asking her to boil it in water and drink it. Unexpectedly, after drinking it a few times, the disease was cured. This mainly shows that Angelica dahurica has the effect of treating menstrual discomfort.

7. Angelica dahurica can treat skin problems. For example, it contains "photoactive substances", such as furanocoumarin compounds such as bergamotol, xanthotoxin, and isoimperatorin, which can effectively treat vitiligo. Angelica dahurica can also inhibit the occurrence of dermatitis.

8. Dispel wind and cold. Angelica dahurica can treat colds, headaches, rhinitis and toothaches caused by wind and cold.

9. Promote blood circulation and discharge pus, used for sores, swelling and pain. For example, if mastitis is just in its early stages, it can be used together with dandelion and trichosanthes. If pus is not draining smoothly, it can be used together with honeysuckle and radix trichosanthis.

10. Promote tissue regeneration and relieve pain. Angelica dahurica has the effect of removing blood stasis, promoting tissue regeneration, reducing inflammation and relieving pain for lumbar muscle strain and muscle soreness.

11. Drying dampness and stopping leucorrhea. Angelica dahurica warms the body and dries out dampness and coldness. It is mainly used to treat leucorrhea caused by dampness and coldness. It is often used together with cuttlebone. If it is caused by damp-heat, it can also be used together with heat-clearing and dampness-drying drugs such as Phellodendron chinense and Toona sinensis root bark.

Effects of Angelica dahurica

Anti-inflammatory effects

Oral administration of 4 g/kg of Angelica dahurica or Angelica dahurica decoction (1 g equivalent to 1 g of the raw drug) to mice significantly inhibited the inflammation of the mouse ears caused by xylene (P<0.01).

Antipyretic and analgesic effects

In an animal model of high fever created by subcutaneous injection of peptone into the back of white rabbits, 1g of Angelica dahurica or 15g/kg of Angelica dahurica decoction had a significant antipyretic effect. Oral administration of 8 g/kg Angelica dahurica or Angelica dahurica decoction significantly reduced the number of writhings induced by intraperitoneal injection of 1% acetic acid (0.1/kg) in mice, which was similar to the effect of 8 mg/kg aminopyrine, P<0.001. In the hot plate test on mice, those with a pain threshold within 30 minutes before administration were given 8g/kg of Angelica dahurica or Angelica dahurica by oral gavage. 60 minutes after administration, the pain threshold of Angelica dahurica and Angelica dahurica dahurica was significantly increased, P<0.001 and 0.01 compared with the saline group.

Antispasmodic effect

The bergamot lactone, zanthoxylum toxin and isoimperatorin B contained in it have obvious antispasmodic effect on rabbit ileum. Isoprugine can also increase the contractility of the rabbit uterus and the tension of the earthworm muscle. Scopolamine has an antispasmodic effect on uterine spasms in rats in vivo or in vitro induced by estrogen or barium chloride, with an ED50 of 0.09 mg/kg.

Effects on cardiovascular system

The isoimperatorin and quinceanine contained in this product have a blood pressure-lowering effect on cats. 50 mg/kg can reduce arterial pressure by 50%, and the effect lasts for 1.5 hours. The copolymer of isoimperatorin and N-vinylpyrrolidone can prolong the time of lowering arterial pressure in cats by 5-10 times. It can also reduce the contractile force of isolated frog hearts.

Antibacterial effect

Angelica dahurica decoction has inhibitory effects on Escherichia coli, Shigella dysenteriae, Proteus, Salmonella typhi, Salmonella paratyphi, Pseudomonas aeruginosa, Vibrio cholerae, and Mycobacterium tuberculosis.

The oxypreparatatin contained in this product has antibacterial effect on 11 strains in vitro; imperatorin also has antibacterial effect on Zanthoxylum bungeanum toxin; the MIC of which against human Mycobacterium tuberculosis H37RV is 100mcg/ml. The water extract also has a certain inhibitory effect on pathogenic fungi such as Microspores of Ringworm.

Photosensitization

The furanocoumarin compounds such as bergamotol, zanthoxylum toxin, and isoimperatorin B contained in this product are photoactive substances. Once they enter the body and are exposed to sunlight or ultraviolet rays, they can cause solar dermatitis on the exposed skin, resulting in redness, swelling, increased pigmentation, and thickening of the skin.

The photosensitizing activity of Zanthoxylum bungeanum is the strongest, followed by bergamotolone, and isoimperatorin B is the weakest. Photosensitizing substances can be used to treat vitiligo. Isoimperatorin is an active ingredient for the treatment of psoriasis, and its effectiveness has been clinically proven by erythema dose measurement.

Anticancer Effects

Isoproteroside and angelicain have cytotoxic effects on Hela cells. The ED50 of isoimperatorin is 100 μg/ml.

Anti-radiation effect

Intraperitoneal injection of 1g/kg of Angelica dahurica methanol extract 5 minutes before X-ray irradiation has a protective effect on mouse skin damage.

Blood pressure lowering effect

The isoimperatorin and Indian quince contained in Angelica dahurica can lower blood pressure for cats, and the effect lasts for 1.5 hours.

What are the effects and functions of Angelica dahurica? The above is a detailed answer to this question. I believe that now everyone should have more knowledge and understanding of the effects and functions of Angelica dahurica. I hope that the above content can help more people better understand and recognize the effects and functions of Angelica dahurica.