Three Chinese patent medicines for anxiety

Many people will suddenly feel anxious, have headaches, fatigue, depression, hot flashes, etc. This is an early symptom of depression. According to medical research, the disease can be treated by taking three Chinese patent medicines: Wuling Capsules, Danzhi Xiaoyao Powder, and Jieyu Pills. These three drugs have passed rigorous medical research and are very effective in treating mild to moderate anxiety and depression. Next, let's learn about the efficacy and effects of these three Chinese patent medicines.

Wuling Capsule: The ingredients are derived from the rare medicinal fungus Wuling fungus in my country, and it is a national first-class new drug. It is suitable for a wide range of people, including the elderly and children. A study comparing Wuling Capsule with paroxetine and Delexin in the treatment of mild and moderate anxiety and depression showed that the drug has anti-anxiety and anti-depressant effects. Its mechanism of action may be that the drug can increase the permeability of the blood-brain barrier to the excitatory neurotransmitter glutamate (GLU) and the inhibitory neurotransmitter γ-aminobutyric acid (GABA), thereby increasing the content of the two in the central nervous system, increasing the activity of glutamate decarboxylase, increasing the synthesis of GABA, and increasing the binding activity of GABA receptors, thereby better demonstrating its sedative, anti-anxiety, anti-epileptic and brain-protective effects.

Danzhi Xiaoyao Powder: Clinical efficacy observation and laboratory research on the treatment of depression. The treatment of depression with compound drugs has attracted the attention of scholars at home and abroad. Some scholars conducted a randomized double-blind controlled trial using the antidepressant maprotiline as the control group, and used a variety of commonly used scales at home and abroad to evaluate efficacy and adverse reactions. The results showed that there was no statistically significant difference in its efficacy in treating depression compared with maprotiline, and the adverse reactions were mild.

Laboratory research results show that Danzhi Xiaoyao Powder can increase the levels of 5-hydroxytryptamine (5-HT) and brain-derived neurotrophic factor (BDNF) in patients with depression, improve the imbalance of monoamine neurotransmitters, promote the regeneration of brain neurons, and also reduce serum cortisol (CORT) and interleukin-6 (IL-6) levels, reduce the activation state of the thalamus-pituitary-adrenal (HPA) axis, and improve the body's immune function. This shows that Danzhi Xiaoyao Powder can adjust the functions of the nervous, immune, and endocrine systems of patients with depression.

Jieyu Pills: Based on many years of clinical treatment experience, it is based on Xiaoyao Powder and Ganmai Dazao Decoction, and is combined with lily, curcuma, julibrissin and other drugs. After 6 weeks of treatment of depression, both Jieyu Pills and Maprotiline can significantly reduce the scores of Hamilton Depression Rating Scale (HAMD), Self-Rating Depression Scale (SDS), Self-Rating Anxiety Scale (SAS) and Clinical Global Assessment Scale (CGI), indicating that the efficacy of Jieyu Pills is equivalent to that of Maprotiline, while the adverse reactions are significantly less than that of Maprotiline.

Laboratory studies have shown that Jieyu Pills have no significant effect on the autonomic activity of mice, can antagonize reserpine and apomorphine to lower the body temperature of mice, and can enhance 5-HT induction to increase the number of head shakes in mice. There is no significant difference compared with fluoxetine, indicating that Jieyu Pills have an antidepressant effect.