Panax notoginseng for treating gastric erosion

Gastric erosion is gastric ulcer, which is a common stomach disease. Panax notoginseng cannot be used to treat gastric erosion because it has the effect of activating blood circulation, but it has no therapeutic effect on stomach diseases. On the contrary, if it is moderate gastric erosion, you may even need to stay away from medicinal materials such as Panax notoginseng. So, what are the medicines that can treat gastric erosion? This will be introduced below!

1. Drugs that enhance mucosal resistance

Carbenoxolone has been shown to accelerate the healing of ulcers in outpatient gastric ulcer patients, but its use is limited because it has the aldosterone-like side effects of licorice (sodium retention, hypertension, hypokalemia). Its mode of action may be related to increasing the production, secretion and viscosity of gastric mucus, inhibiting the activity of pepsin and prolonging the life of gastric mucosal cells. Animal experiments on dogs have shown that carbenoxolone can also greatly reduce the damage of bile to the gastric mucosa. Similar results were obtained in animal experiments with deglycyrrhizinated licorice preparations. Although clinical trials have shown that this preparation is not as effective as carbenoxolone, it has the advantage of fewer side effects. Colloidal bismuth subcitrate, sucralfate, and zinc acetamol are three other drugs that enhance mucosal resistance and have been shown to be as effective as histamine H2 receptor antagonists in healing gastric ulcers. The combination of teprenone and histamine H2 receptor antagonists can not only accelerate the healing of gastric ulcers, but also improve the quality of ulcer healing.

2. Cholestyramine

Cholestyramine can bind to bile acids, so in theory it can reduce the damage of bile acids to the gastric mucosa and accelerate the healing of gastric ulcers. A controlled trial study showed that it did not affect the rate of ulcer healing, but the average ulcer shrinkage rate was higher in patients using cholestyramine. This preparation is also used in patients with bile reflux gastritis and esophagitis after gastric surgery and has a certain effect. Theoretically, the reason why this preparation is not effective may be that bile remains in the stomach for most of the day and night, while the drug stays in the stomach for a very short time. In addition, at around pH 2, the ability of cholestyramine to bind bile acids is also significantly reduced.

3. Histamine receptor antagonists

Histamine H2 receptor antagonists synthesized in recent years can inhibit acid secretion and play an increasingly important role in the treatment of peptic ulcer disease. However, it is not as effective in treating gastric ulcer disease as it is in treating duodenal ulcer disease. Therefore, when treating gastric ulcer, the medication time should be slightly longer than that of treating duodenal ulcer. Rees et al. demonstrated that the combined use of histamine H1 receptor and H2 receptor antagonists can protect the dog's gastric mucosa from bile damage. This result suggests that mucosal damage accompanied by increased ion permeability is mediated by histamine. The findings also suggest that histamine H1 receptor blockers may have therapeutic effects in humans. However, the side effects of current histamine H1 receptor blockers limit their high-dose application.