Anti-thrombotic Chinese patent medicine

As living conditions are getting better and better, there are more and more patients suffering from cerebrovascular and cardiovascular diseases, so anti-thrombotic drugs have gradually come into the public eye. Many people think that Chinese patent medicines are better than Western medicines, so they want to try anti-thrombotic Chinese patent medicines. The most common of this type of medicine is Salvia miltiorrhiza, which is also a commonly used medicine for many patients with hypertension. This article introduces several anti-thrombotic Chinese patent medicines. Let’s take a look.

Chinese herbal medicine for anti-platelet activation

(I) Chinese herbal medicines that inhibit platelet activation

1 Danshensu can inhibit platelet aggregation, increase the level of cAMP in platelets, and reduce the synthesis of thromboxane (TXA2). Danshen can also improve blood rheology, reduce blood viscosity and improve microcirculation. Salvianolic acid can correct calcium homeostasis disorders, inhibit the release of excitatory amino acids and scavenge free radicals. In particular, its antioxidant and free radical scavenging effect is more than 100 times stronger than that of VitE, and also stronger than VitC, mannitol and Ginkgo extract GEb761. It has anti-platelet aggregation and anti-thrombotic effects without obvious effects on the coagulation system, and there is no risk of embolus detachment and bleeding. Therefore, salvianolic acid is a very promising anti-cerebral ischemia drug.

2 Purslane Recently, American scientist Norman Salem Jr. discovered that it contains an unsaturated fatty acid that can inhibit the production of serum cholesterol and triglycerides in the human body, reduce the synthesis of thromboxane A2, and reduce blood viscosity, thereby effectively preventing the occurrence of coronary heart disease. Purslane is also high in potassium, which can work well with protein in the human body to repair damaged tissues and blood vessels, reducing the occurrence of stroke.

3 In vivo administration of crocins can significantly prolong the coagulation time of mice, and has a significant inhibitory effect on ADP- and thrombin-induced platelet aggregation in rabbits, and is dose-dependent. After mice were given platelet aggregation inducers iv, the animals suffered from breathing difficulties due to platelet thrombus formation in the pulmonary microvessels. Crocins can significantly alleviate the symptoms of respiratory distress in mice caused by ADP and AA. Crocins can significantly reduce the wet weight of platelet thrombus formed by common carotid artery-external jugular vein blood flow bypass in rats.

Thrombosis is related to vascular endothelial damage, platelet function and activation of the coagulation system. If blood coagulation can be prevented or platelet function can be inhibited, thrombosis can be prevented. The platelet activation inducer ADP plays a key role in the formation of thrombus, which promotes platelet aggregation and thrombus formation. The results of this experiment showed that crocin inhibited the blood coagulation system and inhibited platelet aggregation, which may be one of its anti-thrombotic mechanisms.

4 Garlic The rare antiplatelet aggregation effect of garlic essential oil was first reported by Bordia. It was later discovered that allicin, diallyl monosulfide, diallyl disulfide, diallyl trisulfide, allicin and ajoene had inhibitory effects on platelet aggregation stimulated by ADP, adrenaline, collagen and arachidonic acid.

5 "Xuesetong" containing PNS from Panax notoginseng can reduce the microviscosity of platelet membrane as the drug concentration and incubation time increase, and can antagonize the effect of low-density lipoprotein on increasing the microviscosity of platelet membrane. Its effect on platelet microviscosity is greater than that on red blood cell membrane. Notoginsengtriol saponins can inhibit platelet aggregation induced by ADP, arachidonic acid, platelet activating factor, and thrombin, and show a dose-effect relationship. The platelet Ca2+ concentration decreases significantly with the increase of Notoginsengtriol saponins dose. PNS has a significant inhibitory effect on experimental thrombosis in rats; intravenous injection can also significantly inhibit the decrease in platelet count and the increase in fibrin degradation products in animals with thrombin-induced disseminated intravascular coagulation.

The effect of PNS on the production of tissue plasminogen activator (t-PA) by endothelial cells was studied. When the concentration of PNS was 0.5g/L and 1.0g/L, the activity of t-PA in the culture medium was significantly increased, while the DNA content of the cells was not significantly different from that in the control group, suggesting that PNS increases t-PA activity not by stimulating endothelial cell proliferation, but by increasing the secretion of t-PA by endothelial cells.