The efficacy and function of Trichosanthes peel

When it comes to the efficacy and functions of Trichosanthes peel , let us first understand Trichosanthes. Trichosanthes is a fruit with high medicinal value. Its fruit is rich in amino acids, sugars, organic acids and other substances. The Trichosanthes peel also has high application value, especially in the treatment of diseases.

The medical value of Trichosanthes peel is far higher than that of Trichosanthes root. With the improvement of medical technology, more and more drugs are available to treat diseases. After high-tech extraction and decomposition, Trichosanthes peel was soon used in medicine.

1. Effect on the cardiovascular system: The water decoction of Trichosanthes peel has a certain inhibitory effect on drug-induced arrhythmias. Experiments show that: the advance intraperitoneal injection of the water decoction of Trichosanthes peel can prevent ventricular fibrillation induced by calcium chloride in rats; it can also significantly increase the threshold dose of ouabain-induced ventricular tachycardia in guinea pigs; it can prolong the latency of arrhythmia induced by aconitine in rats, but there is no statistically significant difference; the intraperitoneal injection of the water decoction of Trichosanthes peel to normal anesthetized rats can significantly prolong the PR, QT, and RR intervals of the electrocardiogram.

2. Effect on the digestive system: Trichosanthes contains laxative substances and has a laxative effect. The laxative effect of Trichosanthes peel is weak; the fatty oil contained in Trichosanthes kernel has a stronger laxative effect; the laxative effect of Trichosanthes frost is relatively mild. The ethanol extract of Trichosanthes kirilowii has an inhibitory effect on the gastric mucosal damage caused by pyloric ligation, 5-hydroxytryptamine, and ethanol hydrochloride. The ethanol extract of Trichosanthes kirilowii has a significant inhibitory effect on the ileal contraction of mice caused by acetylcholine.

3. Antibacterial effect: In vitro tests have shown that the decoction or infusion of Trichosanthes kirilowii has an inhibitory effect on Gram-negative intestinal pathogens such as Escherichia coli, Staphylococcus aureus, Pneumococcus, Type A hemolytic Streptococcus, and Haemophilus influenzae. In addition, it also has an inhibitory effect on skin pathogenic fungi such as Trichophyton audouinensis and Nocardia asteroides.

4. Anti-tumor effect : In vitro experiments have shown that the decoction of Trichosanthes kirilowii and the extracts of Trichosanthes kirilowii peel and Trichosanthes kirilowii seed have a killing effect on mouse ascites cancer cells. The in vitro anticancer effect of Trichosanthes peel is better than that of Trichosanthes seed, and the 60% ethanol extract has the strongest effect. The off-white amorphous powder obtained from the ether extract of Trichosanthes peel also has an anti-cancer effect in vitro, while the seed shell and fatty oil are ineffective. Animal experiments have shown that Trichosanthes has a certain inhibitory effect on sarcoma, but has no obvious effect on ascites cancer.

5. Other effects In vitro experiments show that Trichosanthes injection can significantly inhibit platelet aggregation and TXA2 synthesis induced by ADP and arachidonic acid, and its effect intensity is related to the dose. Intraperitoneal injection of Trichosanthes injection can also significantly reduce the maximum platelet aggregation rate and maximum platelet aggregation velocity after coronary artery ligation for 1 hour and reperfusion for 23 hours. Trichosanthes acid, the active ingredient of Trichosanthes, has a concentration-dependent inhibitory effect on platelet aggregation induced by collagen, adenosine diphosphate and adrenaline. The inhibition of platelet aggregation by Trichosanthes may be related to the inhibition of platelet cyclooxygenase activity and the reduction of TXA2 formation.

Trichosanthes peel has great medical value, but patients are reminded here not to use it indiscriminately. They must follow the doctor's advice, especially for pregnant friends, who should not use drugs indiscriminately. In addition, Trichosanthes peel has therapeutic effects. Whether it is stewed or made into soup, it is delicious and also beneficial to the human body.