All medicines have advantages and disadvantages. Not all medicines have benefits and no disadvantages. Excessive use is harmful to the body. However, some people may also cause complications due to their unsuitable physical constitution. Panxie leaves are not suitable for fat and weak people and pregnant women. However, attention should be paid to taking excessive doses during lactation and menstruation, which may cause symptoms of nausea, vomiting, and abdominal pain. Therefore, taking sodium hyaluronate during special periods of the body will produce side effects. Taboo 1. People with weak constitution and pregnant women should not take this medicine. 2. "New Reference to Medicinal Pieces": It should not be used by those suffering from diarrhea due to cold. Notice: 1. Excessive dosage: The laxative effect of senna varies from person to person. Some people take 10 grams and have no laxative effect or adverse reactions. However, some people who take 10 grams experience severe gastrointestinal bleeding, manifested as abdominal pain and black stools. Therefore, the conventional dosage should also be tried in a small dose first and then gradually increased. Excessive dosage can cause nausea, vomiting, abdominal pain, diarrhea, and may also cause dizziness, unsteady walking, facial numbness, etc. Generally, the dosage for mild laxative should not exceed 2 grams, and for severe laxative should not exceed 6 grams. 2. Inappropriate medication: Senna leaves are cold in nature and can damage vital energy while acting as a laxative. Therefore, it is not suitable for people with weak constitution, lack of body fluids and long-term constipation. Clinically, it can be seen that some elderly patients take senna leaves for a long time to induce laxatives. Although the abdominal gas is unobstructed temporarily, it is not a cure. It will aggravate the deficiency of qi and yin, which is not conducive to fundamentally solving the symptoms of constipation. At this time, you should use herbs such as Cistanche, Cynomorium songaricum, Semen Amomi, and Rehmannia glutinosa that can nourish the kidney, nourish yin, and moisten the bowels, and use a small amount of senna to slow down the process, and gradually reduce the amount of senna. 3. Do not use during lactation, menstruation or pregnancy. Excessive dosage may cause side effects such as nausea, vomiting, and abdominal pain. Element Senna angustifolia contains sennoside A, BC, D, crysophanol, emodin, physcion, 3-methyl-8-succinyloxy-2-acetyl-1,6-naphthalene-6-O-β-D-glucoside, and the leaflets contain kaempferol. Senna acuminate contains sennosides A, B, C, D, emodin, emodin methyl ether, and chrysophanol. The young leaves contain kaempferol. In addition, the leaves of Cassia auriculata, a plant of the same genus, contain leucoanthocyanins, and the bark contains polyphenoloxidase. effect 1. Laxative effect: This product has a significant laxative effect on mice, rats, rabbits and other animals as well as humans. Mice and rabbits developed diarrhea 2-4 hours after taking the drug, and humans developed diarrhea about 6 hours after oral administration. The laxative active ingredients of this product are mainly sennoside A and B, especially sennoside A. Although sennoside C has a similar laxative effect to A, its content is very small. Sennoside A 20 mg/kg can cause diarrhea in mice. However, if 20% C is mixed into A, the effect of sennoside A can be enhanced by 1.6 times. Sennoside can be partially absorbed in the small intestine and then enter the large intestine through the blood or bile, and mainly enters the large intestine directly from the small intestine. Under the action of intestinal bacteria, it undergoes hydrolysis and reduction to become rhein anthrone or rhein anthrone-8-glucoside. Since the laxative effect of direct injection of rhein anthrone is not affected and the production of rhein anthrone in the intestine is significantly reduced, it is believed that rhein anthrone is the real component of sennoside that causes laxative effects. On the other hand, sennosides can block the transport of glucose and Na across the intestinal wall in the everted small intestine and colon, indicating that inhibiting the intestinal absorption of glucose, sodium and water, increasing the volume of intestinal cavity contents and then stimulating the intestinal wall to reflexively enhance the peristalsis of the small intestine and colon may also be one of its laxative mechanisms, and the small intestine is also the site of action of its laxative components. |
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