What should be paid attention to when detoxifying with strychnine

Many people don't know much about Strychnos nux vomica, let alone what kind of object it is. However, those who know Chinese medicine will know its effects. In Chinese medicine, Strychnos nux vomica is a traditional Chinese medicine, and it is also a relatively common Chinese medicine. It has a good detoxification effect, and of course it has other therapeutic effects. Patients should take it according to the prescription to avoid the side effects of the medicine in the body, which is not good for the treatment of the patient's disease. So what should be paid attention to when detoxifying Strychnos nux vomica?

This product is the mature seeds of Strychnos nux vomica and Strychnos nux vomica of the Loganaceae family. This product is button-shaped, round, and often has one side raised and the other side slightly concave, with a diameter of 1.5 to 3 cm and a thickness of 0.3 to 0.6 cm. The surface is densely covered with gray-brown or gray-green silky hairs, which are arranged radiating from the center to the surrounding areas and have a silky luster. The edge is slightly raised, thick, with a protruding micropyle, and a protruding dot-shaped hilum in the center of the bottom. The texture is hard, and the parallel section shows pale yellowish-white endosperm, which is horny, and the cotyledons are heart-shaped with 5 to 7 veins. Odorless, tastes extremely bitter. Harvest the ripe fruits in winter, remove the seeds and dry them.

Nutritional analysis of Strychnos nux vomica: It can clear the meridians, relieve menstruation and pain, resolve phlegm and resolve nodules, reduce swelling and detoxify. It is mainly used to treat stubborn rheumatism, numbness of the skin, paralysis of limbs, laryngeal paralysis, epilepsy, fractures caused by falls, carbuncle swelling and pain; sequelae of polio, and rheumatoid joint pain.

The poisoned person initially feels cramps in the masseter and neck muscles, difficulty swallowing, and general restlessness. Then the extensor and flexor muscles contract extremely at the same time, resulting in tonic convulsions. Ether can be used for mild anesthesia or barbiturates can be injected intravenously to suppress convulsions, and potassium permanganate can be used for gastric lavage. Toxicity: The median lethal dose of strychnine for subcutaneous injection in mice is 0.47 mg/kg and 0.85 mg/kg, and that of 4-hydroxystrychnine is 0.556 mg/kg; the lethal dose of strychnine for intravenous injection in dogs is 8 mg/kg.

Depending on the processing methods, it can be divided into raw strychnine, processed strychnine, etc. The preparation process of Strychnos nux vomica is to put clean sand in a pot, heat it with high heat, add clean Strychnos nux vomica, stir-fry until the surface is dark brown and small bubbles appear, take it out, sieve out the sand, and let it cool; scalding the sand can reduce its toxicity and facilitate crushing. The processed medicinal materials should be stored in a dry container. The processed Strychnos nux vomica should be sealed and placed in a ventilated and dry place, and the raw Strychnos nux vomica should be kept in a special warehouse.

After being processed by heating methods such as blanching, frying, and boiling in licorice water, the content of strychnine and strychnine in Strychnos nux vomica can be significantly reduced, thereby reducing its toxicity.

Generally, oral administration starts with a small dose and gradually increases the dose until the patient feels slight muscle tremors, which is the maximum dose and the dose cannot be increased any further. It should not be taken raw, in large quantities or for a long time, but can be used intermittently. Musk and Corydalis yanhusuo can enhance the toxicity of Strychnos nux vomica, so they should not be used together.

This product is highly toxic and overdose can easily lead to poisoning. The initial symptoms are headache, dizziness, irritability, followed by stiff neck, tightness of the whole body, and even opisthotonos, clenched hands, clenched teeth, and spasmodic smile on the face. In severe cases, it can cause coma, rapid breathing, dilated pupils, irregular heartbeat, and even circulatory failure and death. Therefore, attention should be paid to the preparation and strict control of dosage.

What should be paid attention to when detoxifying with strychnine? There are many key points that patients should pay attention to. There are clear regulations from purchasing medicinal materials to drinking medicinal materials. When buying medicines, you should go to a regular Chinese medicine pharmacy or hospital to buy them. When decocting medicine, one needs to choose the equipment, amount of water, heat, etc., and the regulations on taking it are also clear. There is no harm in taking a certain amount of medicine, but it cannot be used at the same time as medicines with the same or opposite effects, otherwise it will affect the treatment effect.