What is estradiol

Women's bodies are very fragile. They need to be well protected in all aspects, especially the uterus, ovaries, and vagina. If there are problems in these areas, it will have a great impact on women's body and mind. Problems with the ovaries and uterus can also lead to infertility in women. Therefore, they need to be fully protected. What is estradiol?

Many people don’t know much about what estradiol is. When choosing it, you should also be careful not to use it casually, otherwise it will cause great harm to your health. The following is a detailed introduction to it.

What is estradiol?

Estradiol is an estrogen therapy that is absorbed through the skin. It can supplement the deficiency of 17-β estradiol secreted by female ovaries, while avoiding the side effects caused by oral administration (breast pain, weight gain, high blood pressure, gallstones and abnormal liver function, etc.). Estrogen can stimulate cells to synthesize DNA, RNA and various proteins in corresponding tissues.

Element:

Estradiol is estradiol-1,3,5(10)-triene-3,17β-diol. Calculated on a dry basis, the C18H24O2 content should be 97.0-103.0%.

【Properties】 This product is white or milky white crystalline powder; odorless.

The product is soluble in dioxane or acetone, slightly soluble in ethanol, and insoluble in water.

Melting point The melting point of this product (Appendix 2, Chinese Pharmacopoeia 1990 Edition, page 15) should be 175-180℃.

Specific rotation: Take the product, weigh it accurately, add dioxane to dissolve it and quantitatively dilute it to make a solution containing 10 mg per 1 ml. Determine it according to the method. The specific rotation should be +75° to +32°.

Adverse reactions:

1. Uncommon or rare adverse reactions that should be noted: ① irregular vaginal bleeding, spotting, breakthrough bleeding, prolonged bleeding or amenorrhea; ② drowsiness; ③ frequent urination or painful urination; ④ severe or sudden headache; ⑤ sudden loss of behavioral coordination, involuntary jerky movements (chorea); ⑥ pain in the chest, upper abdomen (stomach), groin or legs, especially gastrocnemius pain, weakness or numbness of the arms or legs; ⑦ shortness of breath, sudden onset, unexplained; ⑧ sudden slurred speech or pronunciation; ⑨ sudden change in vision (retinal hemorrhage or blood clots); ⑩ increased blood pressure; ⑩ small lumps in the breast; ⑩ depression; ⑩ yellowing of the conjunctiva or skin, pay attention to hepatitis or biliary obstruction; ⑩ rash; ⑩ thick white curd-like vaginal discharge (candidiasis).

2. More common, but often reduced after continued medication: ① abdominal cramps or bloating; ② poor appetite; ③ nausea; ④ ankle and foot edema; ⑤ breast tenderness or (and) swelling; ⑥ weight gain or loss. There may be nausea, vomiting, breast swelling, local pain, and endometrial hyperplasia. This product contains ethanol, which is not allergic to the skin, but may cause irritation if it comes into contact with mucous membranes.

Through the above introduction, we have a good understanding of what estradiol is. When choosing it, we should not do it blindly, otherwise it will cause serious damage to our health. And when using it, it is best to choose the best one according to the doctor's advice, so that you can use it with confidence.