What are the medicinal values ​​of toad skin?

Everyone must know toads, which are usually amphibians that live in soil or humid places. Everyone knows that frogs and toads are both amphibians, but they are three animals with different uses. When it comes to toads and frogs, everyone may be familiar with them. As for toads, everyone may know that they can also be used as medicinal materials, but what are the specifics? Let's take a look at the medicinal value of toad skin below.

1. Effect on immune function, Cinobufacini, a water-soluble preparation extracted from the whole skin of the Chinese giant toad. Cinobufacini can significantly increase the serum IgG content of normal, immunosuppressed and sensitized mice, and promotes both humoral cell and nonspecific cellular immune functions. Intraperitoneal injection of 0.1 ml of cinona injection per mouse for 14 consecutive days can significantly increase the total white blood cell count, the IgG content of mice and the anti-"H" agglutination titer of domestic rabbits, but can only increase the percentage of T lymphocytes by 19%. Intraperitoneal injection of 10 ml/(kd·d)×7d had no effect on the serum IgG content of normal mice, but could significantly increase the phagocytic percentage and phagocytic index of peritoneal macrophages in mice. It was also found that cytochrome P400 has a mitigating and antagonistic effect on the decrease in leukocytes, the percentage of lymphocytes and the decrease in IgG caused by cyclophosphamide, and can also increase the body's serum IgG antibody level under antigen stimulation.

2. Inhibitory effect on hepatitis B: Huachansu can significantly inhibit the replication of DHBV and has a strong antiviral effect. 1ml/kg and 3ml/kg of Cinobufacini were intramuscularly injected into ducks infected with hepatitis B virus (DHBV). 3ml/kg of Cinobufacini had a significant improvement on duck liver pathology, but the serum DHBV DNA content of 3 ducks slightly rebounded after drug withdrawal, indicating that the compound failed to completely inhibit DHBV until the supercoiled structure of the virus was destroyed. At the same time, clinical observations and in vitro experiments using 2215 cells found that the anti-DHBV efficacy of Cinobufacini increased with increasing dosage.

3. Anti-cancer effect. Oral administration of 20g/kg of Cinobufacini significantly inhibited the growth of mouse tumors (S180), mouse hepatocarcinoma solid type (Heps), mouse reticulocyte tumor (L2), etc., with an inhibition rate of more than 30%; while 8g/kg and 3g/kg of Cinobufacini had a certain inhibitory effect on the three tumor strains but it was not significant. At the same time, the mouse back hair became soft and shiny, and the weight gain was more obvious than that of the blank group and the cyclophosphamide group, indicating that the strength of the inhibitory effect on tumor growth has a certain dose-effect relationship with the dose, which also suggests that it does not harm normal cells while inhibiting tumor growth. There are also reports that compound toad skin capsule has radiation enhancement and a certain degree of protection against side effects caused by radiation. The inhibition rate of 10 μg of arenabufagin extracted from fresh toad skin on the growth of mouse P388 leukemia cells was 52%.

As for the medicinal value of toad skin, you can see that the above article introduces three benefits of toad in detail. It is because toads contain a special substance that is very effective in treating cancer and hepatitis B. So if you have the opportunity, you must make good use of it. This is also for your own health.