The role of interleukins

Medicines are very helpful for the treatment of diseases, especially different medicines have different effects on the treatment of diseases. Therefore, you can choose medicines according to your own needs, which is very helpful for the improvement of diseases. Interleukin is a less common medicine. It also has many aspects in the treatment of diseases. What are the effects of interleukin?

What are the effects of interleukin? This type of drug is used to treat some complex diseases, so it is not usually an option. The following is a detailed introduction to some of its effects.

The role of interleukin:

Interleukin 2 (IL-2) is a glycoprotein with a molecular weight of 15,000 that plays a role in T cell activation and growth. IL-2 is mainly produced by CD4+ and CD8+ T cells, and IL-2 mainly exerts its effects in an autocrine or paracrine manner. Among different species, IL-2 is binding upward along the species spectrum but not downward. IL-2 is an important cytokine involved in immune response and is involved in anti-tumor effects and transplant rejection.

Effects of IL-2 on T cells

IL-2 is a T cell growth factor that can enable T cells to survive for a long time in a test tube and stimulate T cells to enter the cell division cycle. IL-2 can enhance the killing activity of T cells. In vitro, it, together with IL-4, IL-5 and IL-6, induces the production of cytotoxic T cells (Tc), greatly enhances their activity and prolongs their growth period. In vivo, IL-2 can also enhance the activity of antigen-induced TC, and can even assist antigens and haptens to directly induce the production of TC in naked mice. TC produced by interleukin-2 induction can produce significant anti-tumor effects after being injected into the body, but TC is not easy to survive in the body. If a small amount of IL-2 is injected at the same time, the survival time of Tc in the body can be significantly prolonged and its anti-tumor effect can be enhanced. IL-2 can also induce T cells to secrete cytokines such as IFN-γ, TNF, and CSF.

Effects of IL-2 on NK cells

IL-2 can promote the proliferation of NK cells and maintain the long-term growth of NK cells. After tumor patients were treated with IL-2, the number of NK cells in their blood increased significantly. IL-2 can enhance NK cell activity both in vivo and in vitro. In vitro, IL-2 can enhance the activity of NK cells in a short period of time. After IL-2 treatment, the activity of NK cells in tumor patients becomes significantly enhanced, and there is a cumulative effect. That is, with the increase of IL-2 dosage and the extension of treatment course, the activity of NK cells also continues to increase. IL-2 can also correct the low activity of NK cells and restore it to normal or exceed normal. Peripheral blood mononuclear cells (PBMC, 10% of which are NK cells) from leukemia patients have significant cytotoxic effects after being cultured with IL-2, and are then transfused back into the patients to treat leukemia. IL-2 can also promote NK cells to secrete IFN-γ and increase their expression of IL-2R+ subunits.

Through the above introduction, we have a good understanding of the role of interleukin. The use of this type of drug is not very common, but it should be noted that any drug should not be used casually, otherwise it will cause some damage to your own health, and if you want to be able to treat your own disease, you must use the right medicine.