How strong is the medicinal property of Cornus officinalis?

What are the medicinal properties of Cornus officinalis? In fact, how much do you know about Cornus officinalis? At present, there are many benefits to eating Cornus officinalis. It is also very good for blood sugar control and can improve one's own immunity. What are the medicinal properties of Cornus officinalis? What are the effects of Cornus officinalis? Let's introduce it to you and see what benefits Cornus officinalis has for the human body.

1. Effect on the immune system: Cornus officinalis can increase the decrease in white blood cells caused by cyclophosphamide and radiotherapy. Both the water extract and alcohol extract of Cornus officinalis can enhance humoral immune function, promote the number of hemolytic plaque blasts in normal and stress-induced immunodeficiency mice and cyclophosphamide-induced immunosuppression mice, and regulate the skin delayed hypersensitivity reaction (cellular immunity) of mice suppressed by the immunosuppressant cyclophosphamide to a near-normal level. Cornus officinalis sugars also have a significant effect in promoting immune response. Oral administration of the decoction of Fructus Officinalis has a certain enhancing effect on humoral immunity, but weakens the function of T lymphocytes. After normal mouse spleen lymphocytes were treated with total glycosides, the ability of cells to produce IL-2 was improved. When injected intraperitoneally, total glycosides reduced IL-2 production by about 20%. Under the action of factors such as IL-2, NK (natural killer) cells and other cells are transformed into broad-spectrum tumor-killing lymphokine-activated killer cells (LAK cells for short). In vitro, total glycosides have a strong inhibitory effect on the production of LAK cells, reducing the production of LAK cells by 34% to 63%.

2. Anti-inflammatory effect: Daily oral administration of 5g/kg, 10g/kg or 20g/kg of Cornus officinalis decoction for 5 or 7 consecutive days can inhibit the increased permeability of peritoneal capillaries in mice caused by acetic acid, the proliferation of bud tissue in rat cotton balls, the swelling of mouse ears caused by toluene, and the swelling of rat foot pads caused by egg white; reduce the content of ascorbic acid in the adrenal glands of rats; and have no significant effect on the content of prostaglandins in the inflammatory tissue of rat foot pads. Total extract of Rhizoma Cyperi inhibits the chemotaxis of synovial cells to inflammatory cells, reduces the infiltration of inflammatory cells into the synovial membrane, and has a therapeutic effect on arthritis.

3. Effect on hemorrhagic shock Intravenous injection of Cornus officinalis injection (each 1 ml of the solution contains 1 g of the raw drug) has a rapid and significant effect of increasing blood pressure on rabbits with hemorrhagic shock caused by bloodletting. The average blood pressure increase was 7.67 kPa (57.5 mmHg), and the average increase in blood pressure cardiac wave amplitude was 4.5 mm. The injection of Cornus officinalis was intravenously administered to rats (8g/kg) and rabbits (10g/kg) with hemorrhagic shock. Under the condition of adequate fluid replacement, the survival time was prolonged, which was particularly obvious when all the blood loss was replaced. The decrease in blood pressure in rats was significantly less than that in the control group.

4. Effect on blood sugar: Cornus officinalis ferment extract has no effect on normal blood sugar in rats. For rats with alloxan-induced and adrenocortical diabetes model, daily oral administration of 7g/kg for 7 consecutive days can significantly reduce blood sugar and increase liver glycogen content. The ether and ethyl acetate extracts of Cornus officinalis also have a significant hypoglycemic effect on diabetic rats induced by streptozotocin. The active ingredient is ursolic acid. The hypoglycemic effect of Cornus officinalis may be related to promoting the secretory function of residual pancreatic β-cells and increasing the utilization of glucose by organs and tissues. In addition, oral administration of 5g/kg and 110g/kg of Cornus officinalis iridoids can significantly increase the serum SOD value of rats with diabetic vascular complications model, and has a protective effect on oxidative stress damage caused by diabetic vascular complications. Total iridoid glycosides also have a protective effect on the endothelium of the thoracic aorta in diabetic rats.

5. Effect of inhibiting platelet aggregation: In vitro administration of Cornus officinalis injection can significantly inhibit rabbit platelet aggregation induced by high concentrations of adenosine diphosphate (ADP) sodium salt, collagen or arachidonic acid; intravenous injection of 8g/kg also showed that it can inhibit ADP-induced rabbit platelet aggregation, indicating that the overall results are consistent with the in vitro test results. In addition, injection of Cornus officinalis can also inhibit thrombosis in the common carotid artery and external jugular vein bypass circulation in rats.

6. Effects on cardiac function and hemodynamics 2-8 g/kg of Cornus officinalis injection was intravenously injected into cats to observe the effects on the cats' cardiac function, hemodynamics, cardiac work and oxygen consumption indicators. The results showed that the injection could enhance myocardial contractility, improve cardiac efficiency, dilate peripheral blood vessels, significantly enhance cardiac pumping function, and increase blood pressure.

The effects of Cornus officinalis are very wide. For example, the medicinal properties of Cornus officinalis mentioned above are very strong. It can affect blood sugar, relieve the occurrence of hemorrhagic shock, and has a good anti-inflammatory effect. At the same time, Cornus officinalis is very effective and can inhibit the formation of platelets, which is very good for disease prevention.