What are the effects and functions of Astragalus polysaccharide

Everyone knows what Astragalus polysaccharide is? What is it used for? In fact, Astragalus polysaccharide is also a kind of traditional Chinese medicine, which can be used to treat many diseases, but this Astragalus polysaccharide is obtained based on the results of purification. In order to treat diseases and better maintain health, many people take Astragalus polysaccharide to improve spontaneous sweating, and some people choose and use Astragalus polysaccharide to control blood deficiency. So what are the effects and functions of Astragalus polysaccharide?

Effects on nonspecific immune function

Astragalus polysaccharide (APS) can significantly enhance nonspecific immune function and humoral immune function, significantly increase the percentage and index of phagocytic sheep red blood cells in mice, promote the formation of serum hemolysin, improve the hemolytic function of plaque-forming cells and the obvious carbonylation effect, and significantly increase the spleen weight. Astragalus polysaccharides were further separated to obtain three monomeric polysaccharides: 1, 2, and 3. Experiments were conducted separately, and the results showed that polysaccharide 1 could increase spleen weight and cell number, but inhibit the immune response of spleen cells to sheep red blood cells. 2 was similar to 1 but weaker, and polysaccharide 3 had no effect. Astragaloside can promote the proliferation and differentiation of lymph node B cells and the formation of plasma cell antibodies. Astragalus can promote the formation of immune-specific rosettes of mouse lymphocytes to sheep blood cells. Astragalus polysaccharide significantly enhanced the phagocytic luminescence intensity of macrophages and inhibited the release of PGE2, but further promoted the release of TNF. Cyclooxygenase inhibitor ibuprofen significantly inhibited the release of PGE2 and TNF, but had no significant effect on phagocytic function. Therefore, it can be suggested that the combination of immune activators and cyclooxygenase inhibitors may become a new drug treatment for traumatic infection.

Effects on humoral immunity

Astragalus has a significant promoting effect on the antibody production function of the normal body. Astragalus exhibits multiple physiological activities in humoral immunity, enhancing the phagocytic activity of mononuclear macrophages, releasing immune active substances from somatic cells and natural killer cells, and inducing interferon and interleukin. One of its antiviral principles may be to enhance the ability of patients' leukocytes to induce interferon. IgE3 of normal people increased significantly after taking Astragalus herb extract tablets. Astragalus can promote the phagocytic function of macrophages, promote the proliferation of B cells and inhibit total complement activity. It can induce the production of interleukins, promote the formation of immune-specific rosettes of mouse lymphocytes on sheep blood cells, and has a significant protective effect on the immune dysfunction caused by immunosuppressants. It is an immunomodulator with bidirectional effects. Astragalus polysaccharides are a type of substance with strong immune activity in Astragalus. They can enhance the phagocytic function of macrophages. From the determination of spleen and thymus weight, hemolysin, hemagglutinin, total number of spleen cells and plaque-forming cells, it can be seen that Astragalus polysaccharides and Astragalus polysaccharides can completely or partially antagonize the immunosuppressive effect of cyclophosphamide or prednisolone.

Effect on cellular immunity Astragalus can promote the body's cellular immune function.

Its effect of enhancing the immune function of human blood lymphocytes may be due to the partial reduction of the activity of inhibitory T cells. Astragalus polysaccharide can increase the gene transcription expression of IL-2mRNA and IL-2RmRNA in activated T lymphocytes after trauma by regulating the content and promoting phosphatidylinositol metabolism. This may be one of the mechanisms by which astragalus polysaccharide corrects post-traumatic cellular immune dysfunction. The regulatory effect of Astragalus on T cells and the cytokines they secrete may be related to its regulation of the production of IgG subclasses.

These are the effects and functions that Astragalus polysaccharides bring to people. These are also the effects and functions of Astragalus polysaccharides on systemic immunity that we introduced. In fact, Astragalus polysaccharides have other benefits to the body. Many people will use Astragalus polysaccharides to kill cells. Astragalus polysaccharides can also be used to treat some cardiovascular diseases. The anti-aging effect is also equally powerful. Everyone should consider this Astragalus polysaccharide.